Investigation of Antioxidant/Oxidant Potential of Some Natural Biomaterials

Recent studies have focused on plant-based antioxidative materials and biomaterials that serve as remedies or preventive agents against oxidative stress-induced damage in organisms. Various methods exist to evaluate the antioxidant potential of these compounds. Antioxidants neutralize free radicals in biological cells, mitigating their harmful effects on living organisms. This study aimed to investigate the $in$ $vivo$ protective effects of naringin, silymarin and ellagic acid which are known to contribute to tissue repair following short-term ischemia/reperfusion (I/R) injury. Three-week-old, clinically healthy, Wistar albino rats (n: 35), weighing 250-300 g, were used in this study. Blood samples were analyzed for plasma paraoxonase (PON), total sialic acid (TSA), total antioxidant capacity (TAC) and total oxidant capacity (TOC), oxidative stress index (OSI) and nitric oxide (NO) levels. Results demonstrated that TSA, TOC and NO levels decreased while TAC and PON levels increased following biomaterial administration ($P$