Total Synthesis of (±)-Minimiflorin and Its Na<sup>+</sup>/K<sup>+</sup>-ATPase and H<sup>+</sup>/K<sup>+</sup>-ATPase Inhibitory Activities
We have now successfully synthesized (±)-minimiflorin, known as a natural product with H<sup>+</sup>/K<sup>+</sup>-ATPase inhibitory activities, <i>via</i> two routes. Considering the structural similarity between H<sup>+</sup>/K<sup>+</sup>-ATPase and Na<sup>+</sup>/K<sup>+</sup>-ATPase, with 60% sequence homology, we measured the Na<sup>+</sup>/K<sup>+</sup>-ATPase inhibitory activities of our synthesized (±)-minimiflorin and found that it has Na<sup>+</sup>/K<sup>+</sup>-ATPase inhibitory activities.
Authors
- Atsushi Nakayama (ORCID: https://orcid.org/0000-0003-4072-3804)
- Yuri Hase (ORCID: https://orcid.org/0000-0002-5306-9808)
- Mitsuhiro Arisawa (ORCID: https://orcid.org/0000-0002-7937-670X)
- Makoto Sako (ORCID: https://orcid.org/0000-0002-4268-7002)
- Kuniaki Suzuki
- Hiroshi Aoyama (ORCID: https://orcid.org/0000-0001-7915-8975)
- Wataru Yamawaki
Institutions
- Hokkaido University (JP)
- Juntendo University Hospital (JP)
- Pharmaceutical Biotechnology (Czechia) (CZ)
- Kumamoto University (JP)
Publication Details
- Journal
- Journal of Natural Products
- Published
- 2025-06-29
- DOI
- https://doi.org/10.1021/acs.jnatprod.5c00463
- Citations
- 1
- Primary Topic
- Plant biochemistry and biosynthesis
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- Takahashi Industrial and Economic Research Foundation
- Japan Agency for Medical Research and Development
- Osaka University
- Nippon Foundation
- Iwatani Naoji Foundation
- Japan Society for the Promotion of Science
- Core Research for Evolutional Science and Technology