Method for Synthesis of Enol Ester Functionalized Sulfonyl Fluorides
Herein, a novel, catalyst-free method for synthesizing enol ester functionalized sulfonyl fluorides is used using 2-chloroprop-2-ene-1-sulfonyl fluoride in a nucleophilic substitution with carboxylic acid derivatives. The method offers mild conditions, short reaction times, high purity, and efficient modification of drug candidates, advancing both organic synthesis and medicinal chemistry.
Authors
- Hanadi A. Katouah (ORCID: https://orcid.org/0000-0001-9044-2491)
- Eman Elsayed Fayad (ORCID: https://orcid.org/0000-0003-2916-0254)
- Hua‐Li Qin (ORCID: https://orcid.org/0000-0002-6609-0083)
- Monday Peter Ajisafe
- Heba H. Mohamedy
Institutions
- Taif University (SA)
- Wuhan University of Technology (CN)
- Umm al-Qura University (SA)
- Division of Chemistry (US)
- Division of Materials Science and Engineering (AU)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2025-06-29
- DOI
- https://doi.org/10.1021/acs.joc.5c00749
- Primary Topic
- Fluorine in Organic Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Taif University
- Wuhan University of Technology