[Compound <i>Centella asiatica</i> formula alleviates <i>Schistosoma japonicum</i>-induced liver fibrosis in mice by inhibiting the inflammation-fibrosis cascade via regulating the TLR4/MyD88 pathway].
CCA mitigates Sj-induced liver fibrosis by targeting TNF, TP53, JUN, and MMP9 to modulate the TLR4/MyD88 pathway, thereby suppressing pro-inflammatory cytokine release, inhibiting hepatic stellate cell activation, reducing collagen deposition, and preventing granuloma formation in the liver.
Authors
- Junjie Wang (ORCID: https://orcid.org/0000-0003-4164-9458)
- Xuechuan LÜ
- Huilong Fang
- Xinyi Li (ORCID: https://orcid.org/0000-0002-1599-3944)
- Yan Yan (ORCID: https://orcid.org/0000-0003-4781-1954)
- Zhifeng Li (ORCID: https://orcid.org/0000-0003-3908-0012)
- Liping Guan
- Yang Zhao
- Hui Gao
- Dong Cao
- Chenxi Hou
- Jingyu Zeng
Institutions
- Xiangnan University (CN)
Publication Details
- Journal
- PubMed
- Published
- 2025-06-20
- DOI
- https://doi.org/10.12122/j.issn.1673-4254.2025.06.20
- Primary Topic
- Medicinal Plants and Neuroprotection
- Type
- article