[CRISPR-Cas9-mediated CDC20 gene knockout inhibits cervical cancer cell proliferation, invasion and metastasis].
CDC20 is highly expressed in cervical cancer tissues, and CDC20 knockdown can suppress proliferation, invasion, and metastasis while enhancing apoptosis of C33A cells, which is closely related with the regulation of the Wnt/β-Catenin signaling pathway.
Authors
- Yanxiu Mo
- Yulan Mo
- Yang Shu (ORCID: https://orcid.org/0000-0002-1596-5943)
- Wang Qi-ben
- Juntong Liu (ORCID: https://orcid.org/0000-0001-9599-4463)
- Ou Xu (ORCID: https://orcid.org/0000-0002-6039-7877)
- Huafei Deng
Institutions
- Shanghai Medical College of Fudan University (CN)
- Shanghai Medical Information Center (CN)
- Shanghai University of Medicine and Health Sciences (CN)
- Xiangnan University (CN)
Publication Details
- Journal
- PubMed
- Published
- 2025-06-20
- DOI
- https://doi.org/10.12122/j.issn.1673-4254.2025.06.09
- Primary Topic
- 14-3-3 protein interactions
- Type
- article