[Therapeutic mechanism of <i>Arctium lappa</i> extract for post-viral pneumonia pulmonary fibrosis: a metabolomics, network pharmacology analysis and experimental verification].
Preliminary findings suggest that <i>Arctium lappa</i> treats fibrosis by regulating metabolism to inhibit EMT and involves the modulation of non-canonical Smad signaling pathways, such as MAPK providing theoretical support for its clinical application and further research in treating PPF.
Authors
- Guoyong Li (ORCID: https://orcid.org/0000-0003-0932-4063)
- Runan Li (ORCID: https://orcid.org/0009-0006-6026-7884)
- Jing Li (ORCID: https://orcid.org/0000-0002-6459-7470)
- Xinhua Wang (ORCID: https://orcid.org/0000-0002-2954-7259)
- Yiting Liu (ORCID: https://orcid.org/0000-0001-8078-6717)
- Hongxia Ke
Institutions
- Guangzhou University of Chinese Medicine (CN)
- Guangzhou University (CN)
- First Affiliated Hospital of Guangzhou Medical University (CN)
- First Affiliated Hospital of Guangzhou University of Chinese Medicine (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- PubMed
- Published
- 2025-06-20
- DOI
- https://doi.org/10.12122/j.issn.1673-4254.2025.06.08
- Primary Topic
- Plant-derived Lignans Synthesis and Bioactivity
- Type
- article