[Pentosan polysulfate alleviates cyclophosphamide-induced interstitial cystitis/bladder pain syndrome in mice by modulating gut microbiota and bile acid metabolism].

PPS ameliorates IC/BPS in mice by remodeling gut microbiota to enhance DCA production and activate TGR5 signaling, suggesting a novel microbiota-bile acid-TGR5 axis that mediates the therapeutic effect of PPS and a therapeutic strategy for IC/BPS by targeting gut-bladder crosstalk.

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Publication Details

Journal
PubMed
Published
2025-06-20
DOI
https://doi.org/10.12122/j.issn.1673-4254.2025.06.16
Primary Topic
Urinary Bladder and Prostate Research
Type
article
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article

[Pentosan polysulfate alleviates cyclophosphamide-induced interstitial cystitis/bladder pain syndrome in mice by modulating gut microbiota and bile acid metabolism].

Peng Wu, Yuexuan Zhu, Zhangrui Zhu
PubMed
Urinary Bladder and Prostate Research
article

[Pentosan polysulfate alleviates cyclophosphamide-induced interstitial cystitis/bladder pain syndrome in mice by modulating gut microbiota and bile acid metabolism].

Peng Wu, Yuexuan Zhu, Zhangrui Zhu
article en

Abstract

PPS ameliorates IC/BPS in mice by remodeling gut microbiota to enhance DCA production and activate TGR5 signaling, suggesting a novel microbiota-bile acid-TGR5 axis that mediates the therapeutic effect of PPS and a therapeutic strategy for IC/BPS by targeting gut-bladder crosstalk.

PubMedVol. 45(6)
Southern Medical University (CN)
Urinary Bladder and Prostate Research
DOISourceOpenAlex
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[Pentosan polysulfate alleviates cyclophosphamide-induced interstitial cystitis/bladder pain syndrome in mice by modulating gut microbiota and bile acid metabolism]. — Peng Wu, Yuexuan Zhu, et al. · PubMed (2025) | TGRS Research Map | TGRS