Comparative Analysis of PET/CT with 68Ga-FAPI and 18F-FDG in the Diagnosis of Esophageal Cancer.

Purpose : To study the diagnostic value of PET/CT with 68 Ga-FAPI compared with 18 F-FDG in evaluation of cancer extent of esophageal. Materials and methods : The study included 15 patients (10 men, 5 women) with esophageal cancer. All patients underwent PET/CT with 18 F-FDG and ⁶⁸Ga-FAPI-04 from January to December 2024. Primary tumor, metastases in regional lymph nodes were evaluated by PET/CT with ⁶⁸Ga-FAPI-04 and 18 F-FDG. Histological verification was performed in all cases. Results : PET/CT with ⁶⁸Ga-FAPI-04 demonstrated high level of visualization of metastases in regional lymph nodes. The method finds a little more metastasis in regional lymph nodes in comparison with PET/CT with 18 F-FDG. Conclusion : PET/CT c ⁶⁸GA-FAPI-04 demonstrates promising results in evaluation of cancer extent of esophageal. Further studies on large cohorts of patients are necessary to clarify the role of PET/CT with FAPI-04 for various histological types of esophageal cancer.