Long-term treatment with benzodiazepines and related Z-drugs exacerbates breast cancer: clinical evidence and molecular mechanisms
Long-term clinical use of BZDRs significantly increased the mortality rate of BRCA patients. We provide in vivo and in vitro evidence confirming that BZDRs promote BRCA advancement. We revealed that BZDR-mediated BRCA signaling pathways through GABRA3-ECMs, which promotes metastasis, probably through immune modulation and changes in the tumor microenvironment.
Authors
- Bo-Xiang Zhang (ORCID: https://orcid.org/0000-0003-3806-9719)
- Chin‐Sheng Hung (ORCID: https://orcid.org/0000-0002-9515-2036)
- Jeak Ling Ding (ORCID: https://orcid.org/0000-0003-4578-370X)
- Shu‐Chun Chang (ORCID: https://orcid.org/0000-0001-6364-2404)
- Tsung‐Han Hsieh (ORCID: https://orcid.org/0000-0001-7096-2641)
- Yen‐Yi Lin (ORCID: https://orcid.org/0000-0002-4379-1231)
- Phung-Anh Nguyen
- Wei-Chung Vivian Yang
Institutions
- National University of Singapore (SG)
- Taipei Medical University Hospital (TW)
- STR Biotech (South Korea) (KR)
- Institute of Biomedical Sciences, Academia Sinica (TW)
- Taipei Medical University (TW)
Publication Details
- Journal
- Cellular & Molecular Biology Letters
- Published
- 2025-06-29
- DOI
- https://doi.org/10.1186/s11658-025-00752-4
- Primary Topic
- Neuroscience and Neuropharmacology Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National University of Singapore
- Ministry of Science and Technology, Taiwan
- Taipei Medical University