Total Synthesis of Heterolactone

Verticillane diterpenoids, heterolactone was isolated from the soft coral Heteroxenia Ghardaqensis. The structures, including the absolute configurations, were determined by extensive spectroscopic analysis, singlecrystal X-ray diffraction analysis, calculated ECD spectra, and DP4+ probability analyses. This paper will present the occurrences and functions of the compound in daily life, investigate its retrosynthesis and total synthesis, and illustrate them in graphical form.