The role of acemetacin in pain management

Analgesics can be divided into three main groups as non-opioid, opioid, and adjuvant treatment options. In this review, the place of acemetacin, which is among the non-steroidal anti-inflammatory drugs (NSAIDs) in the non-opioid group, in pain treatment was evaluated. Acemetacin is a prodrug and acts by converting to indomethacin in the body. Clinical studies have shown that acemetacin is an effective and safe treatment option for acute and chronic pain. The main gastrointestinal side effects of acemetacin are complaints such as loss of appetite and nausea, and the severity of the side effects is usually mild to moderate. In conclusion, acemetacin is a good option that is effective orally, has a sufficient analgesic effect, has a low gastrointestinal side effect profile, and does not cause tolerance and addiction in pain treatment.