Effects of Stress, Vagal Nerve Stimulation and Disease Activity on Circulating Cytokines, Quantified by an Ultrasensitive Technique, in Ulcerative Colitis: A Pilot Study
Multiple cytokines were detected at sub-pg/mL levels and many showed relationships to disease activity in patients with ulcerative colitis. Effects exerted by interventions associated with epithelial injury were consistently detected by changes in interleukin-12p70 concentrations, but not other cytokines. <b>Trial Registration:</b> Australian New Zealand Clinical Trials Registry: ACTRN12621000168853 and ANZCTR 12620000569909 [Ultrasound studies]; ClinicalTrials.gov identifier: NCT03908073.
Authors
- Adam D. Farmer (ORCID: https://orcid.org/0000-0003-1902-2640)
- Jason A. Tye–Din (ORCID: https://orcid.org/0000-0001-7687-9654)
- Kazuya Takahashi (ORCID: https://orcid.org/0000-0002-3097-9841)
- Peter R. Gibson (ORCID: https://orcid.org/0000-0001-9108-1712)
- Tamara Mogilevski (ORCID: https://orcid.org/0000-0002-8954-2978)
- Melinda Y. Hardy (ORCID: https://orcid.org/0000-0003-4923-0678)
- Qasim Aziz (ORCID: https://orcid.org/0000-0002-2718-2065)
- James O. Lindsay (ORCID: https://orcid.org/0000-0003-3353-9590)
- Rebecca L. Smith (ORCID: https://orcid.org/0000-0002-8033-0848)
- Anke L. Nguyen (ORCID: https://orcid.org/0000-0003-1210-3325)
Institutions
- The Royal Melbourne Hospital (AU)
- Queen Mary University of London (GB)
- Walter and Eliza Hall Institute of Medical Research (AU)
- Barts Health NHS Trust (GB)
- Royal London Hospital (GB)
- Alfred Health (AU)
- Saint Louis University (US)
- Monash University (AU)
Publication Details
- Journal
- JGH Open
- Published
- 2025-06-28
- DOI
- https://doi.org/10.1002/jgh3.70206
- Citations
- 2
- Primary Topic
- Vagus Nerve Stimulation Research
- Type
- article
- Field-Weighted Citation Impact
- 1.68
Funders
- Crohn's and Colitis Foundation of America
- Crohn's and Colitis Foundation
- American Neurogastroenterology and Motility Society
- Monash University
- Crohn's and Colitis UK
- Avant Foundation
- Medical Research Council
- National Health and Medical Research Council