Production of Fine Crystalline Particles Using Vapor–Aeration Method in Anti‐Solvent Crystallization

Abstract Fine crystalline particles with narrow size distribution are desired in pharmaceutical manufacturing, considering the increased bioavailability. This study proposed a vapor–aeration (V–A) method to produce fine crystalline particles with narrow size distribution due to the overcoming the conventional trade‐off between the supersaturation condition of nucleation and crystal growth. Thus, the effects of V–A method on the crystallization and the characteristics of crystalline particles were investigated. Experimental results showed that the V–A method could induce nucleation effectively even under low supersaturation conditions and provide fine crystalline particles with improved size distribution due to its nucleation enhancement.