N-palmitoyl glycine mediates depression-associated atrial fibrillation via Man1a2-dependent autophagy and NRAP dysregulation
This study demonstrates that N-palmitoyl glycine plays a crucial role in the development of AF in the context of depression. These findings provide potential therapeutic targets for the prevention and treatment of AF following depression.
Authors
- Hong Yao (ORCID: https://orcid.org/0000-0003-3826-934X)
- Siqi Sheng
- Zheng Xue (ORCID: https://orcid.org/0000-0002-0898-138X)
- Yuchen Li (ORCID: https://orcid.org/0000-0001-9879-1207)
- Yanghong Dong (ORCID: https://orcid.org/0009-0008-2682-3917)
- Zengxiang Dong (ORCID: https://orcid.org/0000-0001-5255-3270)
- Xiaohui Jiang (ORCID: https://orcid.org/0000-0003-0994-6719)
- J Chen
- Jiahao Li (ORCID: https://orcid.org/0009-0001-5933-7367)
- Zhiqi Wang (ORCID: https://orcid.org/0000-0002-3455-9385)
- Jinhui Zhang (ORCID: https://orcid.org/0000-0002-2677-4480)
- Song Zhang (ORCID: https://orcid.org/0000-0002-3149-6171)
- Yongkang Wei
- Tingting Jiang (ORCID: https://orcid.org/0000-0002-5250-613X)
- Lin Lv (ORCID: https://orcid.org/0000-0003-4474-1938)
- Ning Fang (ORCID: https://orcid.org/0000-0001-7000-0207)
- Z. Liang (ORCID: https://orcid.org/0000-0002-7149-7400)
Institutions
- Harbin Medical University (CN)
- The First Hospital of Kunming (CN)
- First Affiliated Hospital of Harbin Medical University (CN)
Publication Details
- Journal
- EP Europace
- Published
- 2025-06-24
- DOI
- https://doi.org/10.1093/europace/euaf127
- Primary Topic
- Atrial Fibrillation Management and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ministry of Science and Technology of the People's Republic of China