Estimated US Trends in SARS-CoV-2 Spike Antibody Concentrations and Correlation to Risk of First-Time Infections Based on Blood Donations, 2022
During 2022, this nationwide study showed mildly increased S IgG concentrations over time among blood donors. Vaccination and hybrid immunity resulted in higher antibody concentrations than infection alone. Higher antibody concentrations were associated with increased protection from infection.
Authors
- Jefferson M. Jones (ORCID: https://orcid.org/0000-0003-4974-9058)
- Melissa Briggs Hagen (ORCID: https://orcid.org/0000-0001-7359-9665)
- Valerie Green (ORCID: https://orcid.org/0000-0002-7101-3111)
- Brad J. Biggerstaff (ORCID: https://orcid.org/0000-0002-3105-3530)
- Rebecca V. Fink (ORCID: https://orcid.org/0000-0003-3255-4756)
- David J. Wright (ORCID: https://orcid.org/0000-0001-8666-4155)
- Melissa M. Coughlin (ORCID: https://orcid.org/0000-0003-1843-6251)
- Eduard Grebe (ORCID: https://orcid.org/0000-0001-7046-7245)
- Paula Saá (ORCID: https://orcid.org/0000-0001-6077-4532)
- Bryan R. Spencer (ORCID: https://orcid.org/0000-0002-9008-9154)
- Mars Stone (ORCID: https://orcid.org/0000-0001-5619-2767)
- Marion C. Lanteri (ORCID: https://orcid.org/0000-0002-4213-5013)
- Irene Molina Manrique
- Jean D. Opsomer (ORCID: https://orcid.org/0000-0002-9508-5021)
- M. Busch (ORCID: https://orcid.org/0000-0003-4961-6511)
- Isaac Lartey
- Akintunde Akinseye
Institutions
- Centers for Disease Control and Prevention (US)
- Westat (United States) (US)
- American Red Cross (US)
- University of California, San Francisco (US)
- National Center for Immunization and Respiratory Diseases (US)
- Pacific Research Institute (US)
- National Center for Emerging and Zoonotic Infectious Diseases (US)
- Vitalant (US)
- Creative Thermal Solutions (US)
Publication Details
- Journal
- The Journal of Infectious Diseases
- Published
- 2025-06-20
- DOI
- https://doi.org/10.1093/infdis/jiaf329
- Citations
- 1
- Primary Topic
- SARS-CoV-2 and COVID-19 Research
- Type
- article
- Field-Weighted Citation Impact
- 1.40
Funders
- Centers for Disease Control and Prevention