Cord blood levels of insulin‐like growth factor‐1 and insulin‐like growth factor binding protein‐3 correlate with perinatal brain development in fetal congenital heart disease

IGFBP-3 levels were demonstrated to be reduced in neonates with CCHD, and cases with lower predicted COD demonstrated decreased levels of IGF-1 and IGFBP-3. In addition, lower IGF-1 and IGFBP-3 levels at birth were associated with reduced early volumetric brain development. These results indicate that a compromised oxygenation profile in utero in fetuses with CCHD may influence the IGF axis, possibly contributing to impaired brain growth in CCHD. © 2025 The Author(s). Ultrasound in Obstetrics & Gynecology published by John Wiley & Sons Ltd on behalf of International Society of Ultrasound in Obstetrics and Gynecology.

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Publication Details

Journal
Ultrasound in Obstetrics and Gynecology
Published
2025-06-28
DOI
https://doi.org/10.1002/uog.29271
Citations
1
Primary Topic
Congenital heart defects research
Type
article
Field-Weighted Citation Impact
0.81

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article

Cord blood levels of insulin‐like growth factor‐1 and insulin‐like growth factor binding protein‐3 correlate with perinatal brain development in fetal congenital heart disease

Maaike Nijman, Mireille N. Bekker, Manon J.N.L. Benders, Nathalie H.P. Claessens et al.
1 citations
Ultrasound in Obstetrics and Gynecology
Congenital heart defects research
0.81
article

Cord blood levels of insulin‐like growth factor‐1 and insulin‐like growth factor binding protein‐3 correlate with perinatal brain development in fetal congenital heart disease

Maaike Nijman, Mireille N. Bekker, Manon J.N.L. Benders, Nathalie H.P. Claessens, Josine E. G. Vaes, Roel de Heus, Inge M van Ooijen, Nicolaas J. G. Jansen, Raymond Stegeman, Johannes M. P. J. Breur, Cora H. Nijboer, Lieke Reijn
article en
1 citations

Abstract

IGFBP-3 levels were demonstrated to be reduced in neonates with CCHD, and cases with lower predicted COD demonstrated decreased levels of IGF-1 and IGFBP-3. In addition, lower IGF-1 and IGFBP-3 levels at birth were associated with reduced early volumetric brain development. These results indicate that a compromised oxygenation profile in utero in fetuses with CCHD may influence the IGF axis, possibly contributing to impaired brain growth in CCHD. © 2025 The Author(s). Ultrasound in Obstetrics & Gynecology published by John Wiley & Sons Ltd on behalf of International Society of Ultrasound in Obstetrics and Gynecology.

Ultrasound in Obstetrics and GynecologyVol. 66(2)
University Medical Center Groningen (NL), School of the Art Institute of Chicago (US), Leiden University Medical Center (NL), University Medical Center Utrecht (NL), St. Antonius Ziekenhuis (NL), Zero to Three (US), Wilhelmina Children's Hospital (NL)
ZonMw
Good health and well-being
Openalex Percentile: Top 26%
Congenital heart defects research
0.81
DOIOpen Access PDFOpenAlex
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