Comprehensive profiling of the mutational landscape of hidradenoma papilliferum validates key role of alterations in the phosphoinositide 3-kinase/AKT pathway
Comprehensive characterization of the mutational landscape of hidradenoma papilliferum (HP) identified PIK3CA and PIK3R1 as mutually exclusive driver genes. Taken together with the mutation of other genes involved in phosphoinositide 3-kinase/AKT signalling, our findings confirm a key role of the alteration of this pathway in the pathogenesis of HP. The absence of a significant presence of human papillomavirus (HPV) sequences suggests that HPV is not involved in the aetiology of HP.
Authors
- Thomas Brenn (ORCID: https://orcid.org/0000-0002-0089-0352)
- Saamin Cheema (ORCID: https://orcid.org/0000-0002-5297-2042)
- Mark J. Arends (ORCID: https://orcid.org/0000-0002-6826-8770)
- Kim Ping Wong (ORCID: https://orcid.org/0000-0003-1072-6262)
- Ian Vermes
- Martin Del Castillo Velasco‐Herrera (ORCID: https://orcid.org/0000-0001-5956-0211)
- Louise van der Weyden (ORCID: https://orcid.org/0000-0002-0645-1879)
- Steven D. Billings (ORCID: https://orcid.org/0000-0002-2278-5908)
- Carlos Couceiro Monteagudo (ORCID: https://orcid.org/0000-0002-9381-9976)
- Derek Frew (ORCID: https://orcid.org/0000-0002-0890-1415)
- Michiel P J van der Horst
- Ingrid Ferreira (ORCID: https://orcid.org/0000-0002-4321-5250)
- Laura Allen (ORCID: https://orcid.org/0000-0002-2033-7298)
- Nicolas de Saint Aubain
- Carolin Mogler (ORCID: https://orcid.org/0000-0003-3400-7254)
- Ahmed Al‐Omari (ORCID: https://orcid.org/0000-0002-3776-5053)
- David J. Adams (ORCID: https://orcid.org/0000-0001-9490-0306)
- Elizabeth Anderson
- Jamie Billington
Institutions
- Cleveland Clinic (US)
- Université Libre de Bruxelles (BE)
- Universitat de València (ES)
- University of Michigan (US)
- Western General Hospital (GB)
- Institut Jules Bordet (BE)
- Wellcome Sanger Institute (GB)
- Edinburgh Cancer Research (GB)
- Maasstad Ziekenhuis (NL)
- Biomedical Research Institute (US)
- INCLIVA Health Research Institute (ES)
- Indiana University School of Medicine
- Indiana University – Purdue University Indianapolis (US)
- Technical University of Munich (DE)
Publication Details
- Journal
- British Journal of Dermatology
- Published
- 2025-06-27
- DOI
- https://doi.org/10.1093/bjd/ljaf257
- Citations
- 1
- Primary Topic
- Cancer and Skin Lesions
- Type
- article
- Field-Weighted Citation Impact
- 2.00