[email protected] nanoparticle for regulates the expression of GSDMB and targeted therapy of tumor

GSDMB, a key protein in pyroptosis, is closely linked to various diseases. Nanomaterials can target and regulate specific pathways. Herein, we report a simple and efficient one-step method to develop multi-enzyme nanoparticles capable of suppressing GSDMB expression. [email protected] can inhibit GSDMB, a capability that neither ZnO nor Cu5.4O possesses. [email protected] with different ratios also exhibits varying inhibitory effects. The [email protected] can be cleared quickly in vivo, ensuring biocompatibility. Additionally, [email protected] significantly inhibits tumor progression, offering promising avenues for clinical cancer therapy, and the development of gene-regulating nanoparticles.