Breast Cancer Cell Lines <scp>AT</scp> ‐3 and <scp>E0771</scp> Decrease Mechanical and Cold Sensitivity, Along With Oestrous Cycle and Inflammatory Marker Alterations, in Wild‐Type <scp>C57BL</scp> / <scp>6J</scp> Female Mice
Cancer-associated pain and altered sensations significantly decrease patient quality of life. In our murine model, we have shown that breast cancer cell lines (AT-3 and E0771) alter mechanical and cold sensitivity. These changes coincided with oestrous cycle changes (AT-3) and mRNA expression changes (E0771). A better understanding of our findings will elucidate different mechanisms of action while identifying preventative strategies and potential interactions with chemotherapy.
Authors
- Josée Guindon (ORCID: https://orcid.org/0000-0002-2186-1745)
- Ava G. Oliver (ORCID: https://orcid.org/0000-0003-3685-2347)
- Isabel Castro‐Piedras (ORCID: https://orcid.org/0000-0001-5479-123X)
- Anthony Alanis (ORCID: https://orcid.org/0000-0002-9722-7580)
- Margaret Coulter (ORCID: https://orcid.org/0009-0005-0158-0718)
- Saba Javed (ORCID: https://orcid.org/0000-0002-1028-8904)
- Sharilyn Almodóvar (ORCID: https://orcid.org/0000-0002-4769-1924)
- Igor Ponomarev (ORCID: https://orcid.org/0000-0002-3345-3482)
- Satish Banjara
- Robert C. Barnes
Institutions
- Texas Tech University (US)
- The University of Texas MD Anderson Cancer Center (US)
- Texas Tech University Health Sciences Center (US)
Publication Details
- Journal
- European Journal of Pain
- Published
- 2025-06-28
- DOI
- https://doi.org/10.1002/ejp.70066
- Primary Topic
- Pain Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- CH Foundation
- Texas Tech University
- National Institutes of Health
- National Institute on Alcohol Abuse and Alcoholism
- National Heart, Lung, and Blood Institute
- National Institute on Drug Abuse