Multifunctional Bioactive Cu–Sm-Based Nanozyme Systems for Psoriasis Therapy
As a persistent inflammatory dermatological disorder, psoriasis impacts a global population of millions, with existing therapies frequently limited by side effects, high toxicity, and low effectiveness. Herein, we present the design and synthesis of a copper-samarium (Cu-Sm)-based bimetallic nanozyme (CS NPs) with strong antioxidant and anti-inflammatory characteristics for psoriasis therapy. CS NPs imitate natural antioxidant enzymes and efficiently neutralize H<sub>2</sub>O<sub>2</sub>, <sup>•</sup>OH, and O<sub>2</sub><sup>•-</sup>. Characterization investigations have confirmed the nanoparticles' stability, appropriate Sm doping ratio, and catalytic effectiveness. In vitro, CS NPs decrease ROS levels, restrict keratinocyte proliferation, and regulate inflammatory cytokine release through NF-κB pathway inhibition in HaCaT cells activated with IL-17. In vivo, CS NPs ameliorate IMQ-triggered psoriasiform lesions in mouse models through suppression of epidermal acanthosis, immune cell infiltration, and inflammatory marker expression. These results demonstrate the therapeutic potential of Cu-Sm nanozymes to provide biocompatible and effective psoriasis treatment, offering a viable substitute for conventional therapies.
Authors
- Hao Sun (ORCID: https://orcid.org/0000-0003-4599-5518)
- Ting Hu (ORCID: https://orcid.org/0000-0002-9185-1737)
- Jinsheng Liao (ORCID: https://orcid.org/0000-0002-0797-5332)
- Jiayu Chen (ORCID: https://orcid.org/0000-0001-9396-0059)
- Yuhang Li (ORCID: https://orcid.org/0000-0001-8257-2253)
- Hui Yuan (ORCID: https://orcid.org/0000-0001-9627-1654)
- Xiaofeng Wu (ORCID: https://orcid.org/0000-0002-0044-896X)
- Xiaohua Xie (ORCID: https://orcid.org/0000-0002-1604-9840)
- Can‐Zhong Lu (ORCID: https://orcid.org/0000-0002-8298-4132)
- Peiyuan Wang (ORCID: https://orcid.org/0000-0003-1700-1061)
- Jie Han
- Jiangshan Hu
Institutions
- City University of Hong Kong (HK)
- Xiamen University (CN)
- Chinese Academy of Sciences (CN)
- First Affiliated Hospital of Xiamen University (CN)
- Xiamen Institute of Rare-earth Materials (CN)
- Fujian Institute of Research on the Structure of Matter (CN)
- University of Chinese Academy of Sciences (CN)
- Jiangxi University of Science and Technology (CN)
Publication Details
- Journal
- ACS Biomaterials Science & Engineering
- Published
- 2025-06-28
- DOI
- https://doi.org/10.1021/acsbiomaterials.5c00722
- Citations
- 3
- Primary Topic
- Advanced Nanomaterials in Catalysis
- Type
- article
- Field-Weighted Citation Impact
- 1.55
Funders
- Natural Science Foundation of Xiamen City
- National Natural Science Foundation of China
- Natural Science Foundation of Fujian Province
- Natural Science Foundation of Jiangxi Province