Antifungal and sensitizing effect of cadinane-type sesquiterpenes from <i>Heterotheca inuloides</i> Cass. against azole-resistant <i>Candida</i> species
Sesquiterpenes exhibited moderate antifungal activity against resistant C. glabrata and C. tropicalis. They enhanced the effectiveness of FLU, VOR, and CLO. According to molecular docking, the antifungal and resistance-sensitizing activity could be attributed to the inhibition of lanosterol 14α-demethylase and CDR efflux pump, respectively.
Authors
- Guillermo Delgado (ORCID: https://orcid.org/0000-0002-1394-6300)
- Carlos A. Méndez-Cuesta (ORCID: https://orcid.org/0000-0003-1531-0872)
- T. Hernández (ORCID: https://orcid.org/0000-0001-5041-6264)
- Yesica R. Cruz-Martínez (ORCID: https://orcid.org/0009-0002-5033-4909)
Institutions
- Universidad Autónoma de Tlaxcala (MX)
- Universidad Autónoma de la Ciudad de México (MX)
- Universidad Autónoma Metropolitana (MX)
- Universidad Nacional Autónoma de México (MX)
Publication Details
- Journal
- Journal of Applied Microbiology
- Published
- 2025-06-28
- DOI
- https://doi.org/10.1093/jambio/lxaf160
- Primary Topic
- Fungal Biology and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Universidad Nacional Autónoma de México
- Dirección General de Asuntos del Personal Académico, Universidad Nacional Autónoma de México