Considering Clinical Implementation of Polygenic Scores in Hereditary Cancer Risk Assessment: Recipients’ Perspectives on Influencing Factors and Strategies

Evidence-based strategies should be deployed to address recipients' priority barriers to the clinical implementation of PGS for hereditary cancer risk assessment. Centralising recipient voices in implementation design will improve effectiveness and success.

Authors

Paul A. James (ORCID: https://orcid.org/0000-0002-4361-4657)
Mary‐Anne Young (ORCID: https://orcid.org/0000-0002-2493-6394)
Laura Forrest (ORCID: https://orcid.org/0000-0002-1126-4971)
Rebecca Purvis (ORCID: https://orcid.org/0000-0002-1338-1098)
Natalie Taylor

Institutions

The Royal Melbourne Hospital (AU)
Garvan Institute of Medical Research (AU)
The University of Melbourne (AU)
Peter MacCallum Cancer Centre (AU)
UNSW Sydney (AU)
St Vincent's Clinic (AU)

Publication Details

Journal: Patient
Published: 2025-06-28
DOI: https://doi.org/10.1007/s40271-025-00747-5
Primary Topic: BRCA gene mutations in cancer
Type: article
Field-Weighted Citation Impact: 0.00

Funders

University of Melbourne
Peter MacCallum Foundation

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article

Considering Clinical Implementation of Polygenic Scores in Hereditary Cancer Risk Assessment: Recipients’ Perspectives on Influencing Factors and Strategies

Paul A. James, Mary‐Anne Young, Laura Forrest, Rebecca Purvis et al.

Jun 28, 2025

Patient

BRCA gene mutations in cancer

article

Considering Clinical Implementation of Polygenic Scores in Hereditary Cancer Risk Assessment: Recipients’ Perspectives on Influencing Factors and Strategies

Paul A. James, Mary‐Anne Young, Laura Forrest, Rebecca Purvis, Natalie Taylor

June 28, 2025article en

Abstract

Evidence-based strategies should be deployed to address recipients' priority barriers to the clinical implementation of PGS for hereditary cancer risk assessment. Centralising recipient voices in implementation design will improve effectiveness and success.

PatientVol. 18(6)

The Royal Melbourne Hospital (AU), Garvan Institute of Medical Research (AU), The University of Melbourne (AU), Peter MacCallum Cancer Centre (AU), UNSW Sydney (AU), St Vincent's Clinic (AU)

University of Melbourne, Peter MacCallum Foundation

Openalex Percentile: Top 82%

BRCA gene mutations in cancer

DOI Open Access PDF OpenAlex

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Considering Clinical Implementation of Polygenic Scores in Hereditary Cancer Risk Assessment: Recipients’ Perspectives on Influencing Factors and Strategies — Paul A. James, Mary‐Anne Young, et al. · Patient (2025) | TGRS Research Map | TGRS