Influence of Polygenic Risk on Height and BMI in Adults With a 22q11.2 Microdeletion
The results demonstrate that adult height and BMI can be influenced by the effects of genome-wide common variants in the presence of a rare variant conferring elevated a priori risk. Height-PRS may help refine growth expectations in individuals with 22q11.2 microdeletion.
Authors
- Bernice E. Morrow (ORCID: https://orcid.org/0000-0002-8076-4726)
- Bhooma Thiruvahindrapuram (ORCID: https://orcid.org/0000-0003-1128-008X)
- Ryan K. C. Yuen (ORCID: https://orcid.org/0000-0001-7273-4968)
- Shengjie Ying
- Tracy Heung (ORCID: https://orcid.org/0000-0003-1860-7292)
- Anne S. Bassett
Institutions
- Western University (CA)
- Albert Einstein College of Medicine (US)
- University Health Network (CA)
- Centre for Addiction and Mental Health (CA)
- Mental Health Research Institute (AU)
- University of Toronto (CA)
- Great Ormond Street Hospital (GB)
- Hospital for Sick Children (CA)
- Toronto General Hospital (CA)
- SickKids Foundation (CA)
- Toronto General Hospital Research Institute
- University College London (GB)
Publication Details
- Journal
- Journal of the Endocrine Society
- Published
- 2025-06-27
- DOI
- https://doi.org/10.1210/jendso/bvaf115
- Citations
- 2
- Primary Topic
- Congenital heart defects research
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- University Health Network
- University of Toronto
- Canadian Institutes of Health Research
- National Institute of Mental Health