Contribution of perineuronal nets to hyperexcitability in pilocarpine‐induced <i>status epilepticus</i>
De novo formation of PNNs around interneurons in the CA1 region contribute to hyperexcitability of the cells they surround. This acquisition of PNNs is associated with a compensatory or causative mechanism occurring in the wake of PISE, with implications for PNNs in epileptogenesis and possibly other acquired forms of epilepsy.
Authors
- Dipan C. Patel (ORCID: https://orcid.org/0000-0002-1381-5351)
- AnnaLin M. Woo (ORCID: https://orcid.org/0000-0003-3552-8692)
- Harald Sontheimer (ORCID: https://orcid.org/0000-0002-5843-9871)
- Erik J. Fleischel
Institutions
- University of Virginia (US)
Publication Details
- Journal
- Epilepsia
- Published
- 2025-06-28
- DOI
- https://doi.org/10.1111/epi.18489
- Citations
- 5
- Primary Topic
- Proteoglycans and glycosaminoglycans research
- Type
- article
- Field-Weighted Citation Impact
- 5.76
Funders
- National Institutes of Health