A framework of biomarkers for visual system aging: a consensus statement by the Aging Biomarker Consortium

The visual system is essential for human perception, converting light signals into electrical impulses and transmitting them to the brain to process environmental information. As individuals age, their physiological functions gradually decline, leading to age-related vision impairment that significantly impacts the quality of life in elderly individuals. China is home to the world's largest aging population and faces significant challenges in combating visual system aging through effective treatments and interventions. In response to this challenge, the Aging Biomarker Consortium (ABC) of China has developed a consensus statement on biomarkers of visual system aging by integrating cutting-edge global research and synthesizing evidence-based medicine with clinical expertise. This consensus provides a multi-dimensional evaluation framework encompassing functional, morphological, and molecular biomarkers. Validated biomarkers for each domain are recommended not only to facilitate the early detection of vision changes but also to provide insights into the progression of age-related ocular diseases. By advancing this initiative, ABC aims to revolutionize visual health management in aging societies, ultimately improving outcomes for elderly populations in China and globally.

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Publication Details

Journal
Life Medicine
Published
2025-06-28
DOI
https://doi.org/10.1093/lifemedi/lnaf023
Citations
2
Primary Topic
Retinal Imaging and Analysis
Type
article
Field-Weighted Citation Impact
2.72
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article

A framework of biomarkers for visual system aging: a consensus statement by the Aging Biomarker Consortium

Kangxin Jin, Xuxiang Zhang, Gang Pei, Liang Qingfeng et al.
2 citations
Life Medicine
Retinal Imaging and Analysis
2.72
article

A framework of biomarkers for visual system aging: a consensus statement by the Aging Biomarker Consortium

Kangxin Jin, Xuxiang Zhang, Gang Pei, Liang Qingfeng, Mingguang He, Wenben Chen, Wenru Su, Yangqing Zhang, Shengping Hou, Honghua Yu, Wenjuan Zhuang, Qingjiong Zhang, Biao Yan, Fan Lv, Jiaxu Hong, Yonghao Gu, Jing Qu, Zi‐Bing Jin, Jihong Wu, Shan Li, Zhaoyang Wang, Ruiyang Li, Weiqi Zhang, Si Wang, Guang‐Hui Liu, Chao Ma, Xue Tian, Baoyou Geng, Yun Feng
article en
2 citations

Abstract

The visual system is essential for human perception, converting light signals into electrical impulses and transmitting them to the brain to process environmental information. As individuals age, their physiological functions gradually decline, leading to age-related vision impairment that significantly impacts the quality of life in elderly individuals. China is home to the world's largest aging population and faces significant challenges in combating visual system aging through effective treatments and interventions. In response to this challenge, the Aging Biomarker Consortium (ABC) of China has developed a consensus statement on biomarkers of visual system aging by integrating cutting-edge global research and synthesizing evidence-based medicine with clinical expertise. This consensus provides a multi-dimensional evaluation framework encompassing functional, morphological, and molecular biomarkers. Validated biomarkers for each domain are recommended not only to facilitate the early detection of vision changes but also to provide insights into the progression of age-related ocular diseases. By advancing this initiative, ABC aims to revolutionize visual health management in aging societies, ultimately improving outcomes for elderly populations in China and globally.

Life MedicineVol. 4(4)
Tongji University (CN), University of Science and Technology of China (CN), Beijing Tongren Hospital (CN), Academy of Medical Sciences (GB), Hong Kong Polytechnic University (HK), Wenzhou University (CN), Sun Yat-sen University (CN), Shanghai Jiao Tong University (CN), Capital Medical University (CN), Chinese Academy of Sciences (CN), Chinese Academy of Medical Sciences & Peking Union Medical College (CN), Peking University (CN), Wenzhou Medical University (CN), Beijing Institute of Genomics (CN), Shanghai Chest Hospital (CN), Affiliated Eye Hospital of Wenzhou Medical College (CN), Institute for Stem Cell Biology and Regenerative Medicine (IN), Shanghai Eye Disease Prevention & Treatment Center (CN), Shanghai Ninth People's Hospital (CN), Ningxia Hui Autonomous Region Peoples Hospital (CN), Eye & ENT Hospital of Fudan University (CN), Beijing Anding Hospital (CN), Beijing Anzhen Hospital (CN), Peking University First Hospital (CN), Shanghai First People's Hospital (CN), Guangdong Academy of Medical Sciences (CN), Science and Technology Commission of Shanghai Municipality (CN), Guangdong Provincial People's Hospital (CN), The Fourth People's Hospital of Ningxia Hui Autonomous Region (CN), University of Chinese Academy of Sciences (CN), Institute of Zoology (CN), State Key Laboratory of Medical Neurobiology, Southern Medical University (CN), Academia Sinica (TW)
Openalex Percentile: Top 10%
Retinal Imaging and Analysis
2.72
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