Efficacy of Hybrid Cooperative Complexes of Hyaluronic Acid for Treating Hand Skin Laxity and Thickness: An Ultrasound-Based Evaluation

Background: There is a recent growing interest in hand rejuvenation treatments.Objective: This study aimed to assess the efficacy and safety of hybrid cooperative complexes (HCC) of hyaluronic acid (HA) for addressing hand skin laxity and roughness.Materials and methods: This single-centre case series enrolled women aged 35 to 55 years with hand skin laxity and roughness (N=10).Treatment involved administering 1.5 mL of HCC of HA (3.2% concentration) using a 22G x 50mm microcannula at baseline (T0) and four-weeks (T1).Outcomes were evaluated at T1 and 4-months (T2) through hand grading, the Global Aesthetic Improvement Scale (GAIS), and skin thickness measured via ultrasound.Results: Comparing baseline with T1 and T2, the mean hand grade score (standard deviation) was found to decrease (i.e.improve) when rated by a plastic surgeon (2.11.0 vs 2.01.0 vs 1.30.5, respectively [p<0.05]) or dermatologist (2.80.6 vs 2.20.6 vs 2.10.4 [p<0.001]).Skin thickness (epidermis plus dermis) and total thickness (skin plus subcutaneous layer) increased at T1 and T2.GAIS scores were lower at T2 vs T1, indicating a trend for aesthetic improvement over time.Conclusion: This case series suggests that HCC of HA effectively improve skin laxity and roughness, highlighting their potential as a treatment option.