Mosaic loss of chromosome Y in blood is associated with male susceptibility for idiopathic pulmonary fibrosis
Our results contribute to explaining the profound sex bias in IPF and replicate a mLOY-driven profibrotic disease mechanism first identified in mice. Male IPF patients with mLOY represent a subgroup that may benefit from treatment with TGF-β inhibitors.
Authors
- John S. Kim (ORCID: https://orcid.org/0000-0002-8887-150X)
- Ammar Zaghlool (ORCID: https://orcid.org/0000-0003-1544-8070)
- Imre Noth (ORCID: https://orcid.org/0000-0001-9846-5030)
- Nicholas W. Chavkin (ORCID: https://orcid.org/0000-0001-9058-0245)
- Lars A. Forsberg (ORCID: https://orcid.org/0000-0002-1701-755X)
- Mark C. Thel (ORCID: https://orcid.org/0000-0002-1512-6242)
- Kenneth Walsh (ORCID: https://orcid.org/0000-0001-7580-2276)
- Shwu‐Fan Ma (ORCID: https://orcid.org/0000-0002-3058-9480)
- Kevin J. Anstrom (ORCID: https://orcid.org/0000-0001-6452-2172)
- Jonatan Halvardson (ORCID: https://orcid.org/0000-0002-5533-1953)
- Jonas Mattisson (ORCID: https://orcid.org/0000-0002-4456-9667)
- Josefin Bjurling
- Fernando J. Martínez (ORCID: https://orcid.org/0000-0002-2412-3182)
Institutions
- University of North Carolina at Chapel Hill (US)
- Uppsala University (SE)
- Seattle Children's Hospital (US)
- University of Washington (US)
- Cornell University (US)
- Science for Life Laboratory (SE)
- University of Virginia (US)
Publication Details
- Journal
- Communications Medicine
- Published
- 2025-06-28
- DOI
- https://doi.org/10.1038/s43856-025-00966-9
- Citations
- 5
- Primary Topic
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Type
- article
- Field-Weighted Citation Impact
- 7.59
Funders
- National Aeronautics and Space Administration
- American Heart Association
- Cancerfonden
- Nuclear Safety and Security Commission
- Vetenskapsrådet
- Uppsala Universitet
- National Institutes of Health
- Uppsala Multidisciplinary Center for Advanced Computational Science