Biochemical Indicators of Oral Fluid in Patients with Dental Implants Against the Background of Hepatobiliary Pathology and Pharmacological Support

Annotation. Liver and biliary tract diseases exert systemic effects on the body, causing alterations in metabolic, immune, and trophic processes. Hepatobiliary dysfunction can lead to changes in the composition of biological fluids, including oral fluid, which in turn affects the oral cavity’s microecology, mucosal resistance, and the body's potential response to implant procedures. The aim of the study is to investigate the biochemical parameters of oral fluid in patients undergoing dental implantation against the background of hepatobiliary system pathology and pharmacological support. All patients were divided into three groups: a control group (12 patients) – included healthy individuals undergoing dental implant surgery with standard treatment protocol; the second – comparison group (12 patients) – included patients with hepatobiliary pathology undergoing dental implant surgery with standard treatment protocol; the third – main group (15 patients) – included patients with hepatobiliary pathology undergoing dental implant surgery and receiving, in addition to the standard protocol, hepatoprotective and osteotropic support. For all patients, oral fluid was collected and examined for elastase and lysozyme activity, acid and alkaline phosphatase levels, degree of dysbiosis, and oral fluid mineralization index. The obtained data reliably indicate (p<0.05) the necessity of using Ursokhol and Osteogenon as part of the pharmacological support for patients with hepatobiliary pathology after dental implantation.