The role of biological antiseptic in the treatment of purulent-necrotic complications of soft tissues after abdominal surgery in obese patients

Annotation. The aim of the study is to evaluate the clinical significance of the use of a gel product with collagenase as a biological antiseptic in the treatment of patients with purulent necrotic processes of soft tissues. The relevance of the issue is due to the fact that the treatment of purulent necrotic processes of soft tissues requires significant improvement and the introduction of new technologies, especially from the side of biological antiseptics. Based on observations from 2022 to 2025 of 78 patients with purulent necrotic processes of soft tissues (37 patients in the main group used a drug with collagenase and 41 patients in the comparison group used Levomekol ointment), we noted the positive effect of using a complex drug with collagenase, which allowed the main group to clean the wound in 4.1±1.7 days, while in the comparison group this figure was 5.9±1.9 days (p=0. 00012). Accordingly, this subsequently contributed to earlier wound epithelialization in patients of the main group (7.8±2.1 days) compared with patients of the comparison group (8.4±1.3 days) (p=0.0187). In addition, a positive clinical effect was noted when using a gel with collagenase in the treatment of obese patients with purulent-necrotic complications of soft tissues after abdominal surgery.