Bio-analytical study of Efonidipine Hydrochloride Ethanolate and Telmisartan in human plasma by RP-HPLC

Hypertension is now commonly treated with two or three-drug combinations, often using two drugs. So, a binary drug combination was selected for this analytical study. The formulation comprises Efonidipine HCl Ethanolate (EFN) and Telmisartan (TEL), which treat cardiovascular conditions such as hypertension. Amlodipine was used as the Internal Standard (IS) to develop and validate a new and reliable RP-HPLC analytical technique for the simultaneous analysis of EFN and TEL in human plasma. Method novelty, sensitivity, rapidity, precision, and accuracy were evaluated