Development and evaluation of fluconazole-loaded selenium nanoparticle gel

The purpose of the current research work was to formulate, optimise, and evaluate fluconazole-loaded selenium nanoparticulate gel for the cure of Tinea corporis. Selenium nanoparticle gel wereeffectively prepared by chemical reduction method and optimized by 32factorial design (response surface methodology, design expert version 12)therewere two independent variables was evaluated on (concentration of sodium selenite and sonication time) and two dependent variables with use particle size and entrapment efficiency).The prepared formulation wasassessed in terms of particle size, in vitro drug release, encapsulation efficiency, zeta potential, viscosity and spreadability. Based on response surface methodology, F6 formulation the highest trapping efficiency with of 92.25%, in-vitro drug release of 76.08% in 8 hrs and mean particle diameter of 62.76 nm. The stability studies revealed that all the formulations were stable as none of them exhibited significant change in drug content over time. The study indicated successful development of fluconazole loaded selenium nanoparticulate gel with improved penetration, good homogeneity, enhancement of duration of action. It can thus be concluded that the developed gel could be an effective treatment for management of skin fungal infection.