Compressive Stress and Inflammation Induce Ferroptosis in Periodontal Ligament Cells Through <scp>ACSL4</scp> Activation in Orthodontically Induced Inflammatory Root Resorption
ACSL4-mediated ferroptosis, triggered by compressive stress and inflammation in hPDLCs, contributed to the development of OIIRR. Rosi has been shown to inhibit OIIRR and serve as a novel therapeutic target for OIIRR treatment.
Authors
- Runze Zhang
- Chunmiao Jiang (ORCID: https://orcid.org/0000-0002-9571-0958)
- Jie Zhang
- Wei Tian (ORCID: https://orcid.org/0009-0006-9568-7600)
- Liyan Liu
Institutions
- Qingdao University (CN)
- Affiliated Hospital of Qingdao University (CN)
Publication Details
- Journal
- Orthodontics and Craniofacial Research
- Published
- 2025-06-28
- DOI
- https://doi.org/10.1111/ocr.70002
- Citations
- 3
- Primary Topic
- Inflammatory mediators and NSAID effects
- Type
- article
- Field-Weighted Citation Impact
- 4.18
Funders
- Natural Science Foundation of Shandong Province