Exercise-induced irisin ameliorates cognitive impairment following chronic cerebral hypoperfusion by suppressing neuroinflammation and hippocampal neuronal apoptosis
Our findings demonstrate that enhancing endogenous irisin via FAE mitigates CCH-induced neuronal apoptosis, microglial activation, cognitive impairment, and affective behavioral deficits by promoting autophagy through the integrin αVβ5/AMPK/mTOR signaling pathway.
Authors
- Yibing Yang (ORCID: https://orcid.org/0000-0001-9298-5932)
- Weiping Xiao (ORCID: https://orcid.org/0000-0002-9717-5979)
- Daizhi Yang (ORCID: https://orcid.org/0000-0001-7827-3226)
- Bai Lu (ORCID: https://orcid.org/0000-0001-5418-9759)
- Fanying Li (ORCID: https://orcid.org/0000-0001-9281-6370)
- Yan Yan (ORCID: https://orcid.org/0000-0002-5917-1475)
- Lingzhi Quan
- Runze Li (ORCID: https://orcid.org/0000-0002-0154-2202)
- Liang Feng
- Tiewei Qi (ORCID: https://orcid.org/0000-0002-8435-6738)
- Peixuan Yang (ORCID: https://orcid.org/0000-0002-2768-927X)
- Q Liang
Institutions
- Sun Yat-sen University (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
- Third Affiliated Hospital of Sun Yat-sen University (CN)
Publication Details
- Journal
- Journal of Neuroinflammation
- Published
- 2025-06-28
- DOI
- https://doi.org/10.1186/s12974-025-03493-5
- Citations
- 8
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 6.74
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Basic and Applied Basic Research Foundation of Guangdong Province