Genetically-engineered Salmonella typhimurium expressing FGF21 promotes neurological recovery in ischemic stroke via FGFR1/AMPK/mTOR pathway
Our study presents a novel, Salmonella - based platform for targeted and sustained FGF21 delivery, offering a promising therapeutic strategy for ischemic stroke with robust efficacy and minimal systemic toxicity.
Authors
- Jin Zheng (ORCID: https://orcid.org/0000-0002-5005-9786)
- Kunlin Jin (ORCID: https://orcid.org/0000-0002-1336-348X)
- Qichuan Zhuge (ORCID: https://orcid.org/0000-0002-2427-1927)
- Wenqi Qian (ORCID: https://orcid.org/0000-0003-0928-1542)
- Haoqi Ni
- Yuhao Chen (ORCID: https://orcid.org/0009-0008-2842-3757)
- Su Yang
- Chenguang Yang (ORCID: https://orcid.org/0000-0002-3145-385X)
- Xijun Chen (ORCID: https://orcid.org/0000-0003-4196-508X)
- D.L Xu
- Min Wen
- Yinan Zhou (ORCID: https://orcid.org/0009-0009-0973-1612)
- Bingwa Lebohang Anesu
Institutions
- University of North Texas (US)
- University of North Texas Health Science Center (US)
- Hunan University (CN)
- Wenzhou Medical University (CN)
- First Affiliated Hospital of Wenzhou Medical University (CN)
Publication Details
- Journal
- Journal of Neuroinflammation
- Published
- 2025-06-28
- DOI
- https://doi.org/10.1186/s12974-025-03498-0
- Citations
- 2
- Primary Topic
- Cancer Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.47
Funders
- National Natural Science Foundation of China
- Wenzhou Municipal Science and Technology Bureau
- Natural Science Foundation of Zhejiang Province