ENHANCING INCISED WOUND HEALING IN MICE USING GARCINIA MANGOSTANA STEM BARK AND PERICARP EXTRACTS

Wounds are tissue injuries caused by various external and internal factors that may disrupt the normal function of the affected tissue. Numerous studies have focused on the use of natural substances as complementary therapies to accelerate wound healing. One plant that has demonstrated therapeutic potential is Garcinia mangostana L. This study aimed to evaluate the therapeutic potential of stem bark and pericarp extracts of Garcinia mangostana L. in accelerating the healing of incised wounds in mice (Mus musculus). A Completely Randomized Design (CRD) was employed, consisting of six treatment groups with three replicates each: negative control (K−), positive control (K+), and mice treated with combined extracts of stem bark and pericarp of G. mangostana at concentrations of 25%, 50%, 75%, and 100%. All mice were inflicted with an incised wound measuring 1 cm in diameter. The wound healing process was observed over 13 days, with measurements taken every three days. The results showed that administration of the extracts significantly accelerated the healing of incised wounds in mice. These findings suggest that Garcinia mangostana L. has potential as a complementary therapy to enhance wound healing, providing a basis for further studies on its application in humans.