E3 ubiquitin-protein ligase CBL inhibits non-small cell lung cancer progression via ubiquitination and degradation of KDR
Our findings identify CBL as a functional tumor suppressor in NSCLC that exerts its anti-cancer effects via ubiquitin-mediated degradation of KDR. The CBL-KDR axis signifies a new regulatory route with significant therapeutic potential for NSCLC therapy.
Authors
- Yuxian Shen (ORCID: https://orcid.org/0000-0002-0916-0743)
- Zhiyue Tu
- Hua Long Li (ORCID: https://orcid.org/0000-0002-8786-4295)
Institutions
- Tianjin Medical University Cancer Institute and Hospital (CN)
Publication Details
- Journal
- Cell Division
- Published
- 2025-06-28
- DOI
- https://doi.org/10.1186/s13008-025-00159-9
- Primary Topic
- Ubiquitin and proteasome pathways
- Type
- article
- Field-Weighted Citation Impact
- 0.00