Gait variability as a marker of white matter integrity in individuals with Down syndrome
Gait variability linked to white matter integrity in individuals with Down syndrome (DS). Lower fractional anisotropy and higher mean diffusivity are associated with increased step time variability in DS. Cognitive decline is tied to white matter changes in motor-related brain regions. Gait analysis alongside diffusion tensor imaging may aid in screening for cognitive impairment in DS.
Authors
- Amelia J. Anderson‐Mooney (ORCID: https://orcid.org/0000-0003-3876-0235)
- Amanda C. Glueck (ORCID: https://orcid.org/0000-0002-1978-5165)
- Frederick A. Schmitt (ORCID: https://orcid.org/0000-0003-4315-2488)
- Manal Ibrahim (ORCID: https://orcid.org/0000-0001-5630-2364)
- Ahmed A. Bahrani (ORCID: https://orcid.org/0000-0003-1809-0879)
- Elizabeth Head (ORCID: https://orcid.org/0000-0003-1115-6396)
- Jordan P. Harp (ORCID: https://orcid.org/0000-0003-2089-0883)
- David K. Powell (ORCID: https://orcid.org/0000-0002-6868-5611)
- Kathryn L. Van Pelt (ORCID: https://orcid.org/0000-0002-5494-2357)
- Elizabeth M. Leach
Institutions
- University of Kentucky (US)
- University of Pikeville (US)
- University of California, Irvine (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-06-27
- DOI
- https://doi.org/10.1002/alz.70407
- Citations
- 2
- Primary Topic
- Advanced Neuroimaging Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 2.72
Funders
- National Institutes of Health
- National Institute on Aging