Comparative thromboelastography with platelet mapping assessment of coagulation profiles in postablation vs nonablated patients with paroxysmal atrial fibrillation and peripheral artery disease: Implications for thrombotic risk
Despite catheter ablation's established efficacy for atrial fibrillation (AF), recent reports of unexpected thrombotic events—including rare strokes with pulsed-field ablation—have raised critical questions about post-procedural coagulation dynamics1. Current guidelines recommend standard anticoagulation protocols based primarily on clinical experience, yet specific hemostatic alterations following ablation remain poorly characterized. We hypothesized that ablation-induced myocardial injury creates a persistent prothrombotic state detectable by advanced coagulation testing.
Authors
- Theofanie Mela (ORCID: https://orcid.org/0000-0002-7482-6214)
- Adriana Rodriguez
- Anahita Dua
- Qun Sha (ORCID: https://orcid.org/0000-0002-2335-9062)
- Eric A. Secemsky (ORCID: https://orcid.org/0000-0003-3861-3163)
- Aneesh Bapat (ORCID: https://orcid.org/0000-0002-1996-522X)
- Mounika Naidu Boya (ORCID: https://orcid.org/0000-0002-1635-1118)
- Isabella Ferlini Cieri (ORCID: https://orcid.org/0000-0002-6163-1055)
- Shiv Patel (ORCID: https://orcid.org/0009-0008-2580-436X)
- Andrea Nurko
Institutions
- Beth Israel Deaconess Medical Center (US)
- Harvard University (US)
- Massachusetts General Hospital (US)
- Haemonetics (United States) (US)
- Deaconess Hospital (US)
Publication Details
- Journal
- Heart Rhythm O2
- Published
- 2025-06-27
- DOI
- https://doi.org/10.1016/j.hroo.2025.06.014
- Primary Topic
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health