Physical activity as a resistance or resilience mechanism in Down syndrome Alzheimer's disease
Adults with Down syndrome are genetically at risk for Alzheimer's disease (AD).Timing of AD clinical onset spans 30+ years.Physical activity has been linked to less cognitive decline and dementia symptoms.Physical activity may protect against dementia through resilience mechanisms.Physical activity could be a low-cost intervention to help prevent cognitive decline.
Authors
- Lauren T. Ptomey (ORCID: https://orcid.org/0000-0002-1705-1643)
- Benjamin L. Handen (ORCID: https://orcid.org/0000-0001-9550-1665)
- Charles M. Laymon (ORCID: https://orcid.org/0000-0002-5966-7219)
- Jamie C. Peven (ORCID: https://orcid.org/0000-0002-2187-5514)
- Julianne G. Clina (ORCID: https://orcid.org/0000-0002-3655-5644)
- Brian C. Helsel (ORCID: https://orcid.org/0000-0003-3362-3581)
- Ashlyn Barry (ORCID: https://orcid.org/0000-0001-7899-711X)
- Victoria Fleming
- Matthew Zammit (ORCID: https://orcid.org/0000-0001-8966-8397)
- Sigan L. Hartley (ORCID: https://orcid.org/0000-0002-0186-6282)
- Elizabeth Head (ORCID: https://orcid.org/0000-0003-1115-6396)
- Beau M. Ances (ORCID: https://orcid.org/0000-0003-3862-7397)
- Mark E. Mapstone (ORCID: https://orcid.org/0000-0003-0280-8057)
- Ozioma C. Okonkwo (ORCID: https://orcid.org/0009-0009-8764-811X)
- Bradley T. Christian (ORCID: https://orcid.org/0000-0002-9653-559X)
Institutions
- University of Wisconsin–Madison (US)
- University of Pittsburgh (US)
- University of California, Irvine (US)
- Washington University in St. Louis (US)
- University of California, Irvine Medical Center (US)
- University of Kansas Medical Center (US)
- VA Pittsburgh Healthcare System (US)
Publication Details
- Journal
- Alzheimer s & Dementia Translational Research & Clinical Interventions
- Published
- 2025-06-27
- DOI
- https://doi.org/10.1002/trc2.70127
- Primary Topic
- Frailty in Older Adults
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Waisman Center
- Gruppo Nazionale per il Calcolo Scientifico
- National Institute on Aging
- National Institute of Child Health and Human Development
- Eunice Kennedy Shriver National Institute of Child Health and Human Development