Beyond gold: the chemoenhancing mechanism and therapeutic potential of auranofin in melanoma
This study underscores the chemosensitizing potential of AF in overcoming multidrug resistance in cancer therapy through redox modulation. The molecular mechanism of action underlying AF on TrxR1 demonstrated the unique binding configuration that impedes the reduction of Trx by TrxR1 and instigates an apoptotic response in cancer cells. These findings pave the way for the clinical application of AF as a chemosensitizer, offering a novel approach to augment the efficacy of existing chemotherapy regimens.
Authors
- Qi Li (ORCID: https://orcid.org/0000-0002-4635-5128)
- Wuqiong Zhang (ORCID: https://orcid.org/0000-0002-5104-667X)
- Li Su (ORCID: https://orcid.org/0000-0002-4136-4770)
- Yanqiao Zeng
- Zhongda Li
- Yingnan Liu (ORCID: https://orcid.org/0009-0000-8784-0528)
- Jiaxin Chen (ORCID: https://orcid.org/0000-0003-1506-2223)
- Yang Li (ORCID: https://orcid.org/0000-0001-7242-4687)
- Guofang Zhang (ORCID: https://orcid.org/0000-0002-4616-2721)
- Xiaofeng Wang (ORCID: https://orcid.org/0000-0001-8424-419X)
- Xiaoman Suo
Institutions
- Academy of Mathematics and Systems Science (CN)
- Shenzhen Institutes of Advanced Technology (CN)
Publication Details
- Journal
- Cancer Biology and Medicine
- Published
- 2025-06-27
- DOI
- https://doi.org/10.20892/j.issn.2095-3941.2025.0026
- Primary Topic
- Redox biology and oxidative stress
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Guangdong Province