T‐cell differentiation stage block bias confers hypermethylation and mediastinal preference in T‐cell lymphoblastic lymphoma
Malignant T cells in T-LBL are primarily blocked in the DN and DP stages, which contributes to the immunosuppressive TME and mediastinum preference of T-LBL. The active transcription factor E2F2 in the DP and DN stages upregulates UHRF1 expression, leading to the hypermethylation of tumor suppressor genes in T-LBL. Demethylation therapy targeting the hypermethylation of tumor suppressor genes mediated by UHRF1 effectively inhibits tumor proliferation in T-LBL.
Authors
- Tingting Yang (ORCID: https://orcid.org/0000-0002-8645-9415)
- Le Xia
- Xiaowen Yu (ORCID: https://orcid.org/0000-0001-8886-0432)
- Chunlei Zhou (ORCID: https://orcid.org/0000-0002-0862-2184)
- Yongjun Fang (ORCID: https://orcid.org/0000-0002-1081-6471)
- Bo Qian (ORCID: https://orcid.org/0000-0002-6964-220X)
- Gang Zhang (ORCID: https://orcid.org/0000-0001-7697-7203)
- Jiali Wang (ORCID: https://orcid.org/0000-0002-3640-5910)
- Yaping Wang (ORCID: https://orcid.org/0000-0001-6122-2756)
- Yidan Zhang (ORCID: https://orcid.org/0000-0001-6691-5244)
Institutions
- Anhui Medical University (CN)
- Huaian First People’s Hospital (CN)
- Second Affiliated Hospital of Nanjing Medical University (CN)
- Ministry of Education and Child Care (CA)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Clinical and Translational Medicine
- Published
- 2025-06-27
- DOI
- https://doi.org/10.1002/ctm2.70380
- Citations
- 1
- Primary Topic
- Lymphoma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.47
Funders
- National Natural Science Foundation of China