Lipidomics Analysis of Sensitive Skin Aging in Chinese Women Aged 22-28 and 29-35 Years Based on the Division of Women’s Life Rhythm in the Yellow Emperor Internal Classic

Purpose: To explore sensitive skin facial physiological parameters and lipid differences caused by skin aging. Methods: Female volunteers with sensitive skin were enrolled into the S1 group (22-28 years old) and the S2 group (29-35 years old). Skin surface lipid samples and physiological parameters were collected by non-invasive methods. Ultra-performance liquid chromatography quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF-MS) techniques and partial least squares-discriminant analysis (PLS) were used to identify differential lipids. Results: Significant differences in skin elasticity, b* value and ITA was observed between S1 and S2 groups (<i>p</i><0.05). In lipid profiling analysis, the two groups displayed a good degree of separation. There were five VIP lipids with significant differences between the two groups, including PA(20:0/22:2(13Z,16Z)) and Cer(d18:0/24:0). Lipids showed a significantly correlation with skin elasticity and ITA value (<i>p</i><0.05). According to ROC analysis, the AUC values of PG(20:0/22:1 (11Z)) and Cer(d18:0/24:0) are greater than 0.7. The results showed that the prediction performance of these two lipids was better and more representative than other lipids. Conclusion: Compared with S1 group, the facial barrier function of the volunteers in S2 group did not change significantly, indicating that the effect of sensitive skin on the skin was stronger than the change of age on the skin barrier function in a certain period of time. Significant changes in elasticity, radiance and differential lipids involved in inflammation indicate that the volunteers in S2 group had exhibited a trend of early aging along with inflammatory aging.