Anti-inflammatory Potential of Oleogel Calophyllum inophyllum L (Nyamplung) from Coastal Sabang City

This research aims to explore the anti-inflammatory potential of oleogel made from nyamplung seed oil (Calophyllum inophyllum L.) originating from the coastal area of Sabang City, Aceh Province. Nyamplung seed oil is known to contain secondary metabolites that have anti-inflammatory potential, in addition to its high antioxidant activity. The use of nyamplung seed oil as a natural medicinal ingredient is very important considering the high consumption of non-steroidal anti-inflammatory drugs (NSAIDs) which can cause side effects such as kidney damage. The aim of this research is to develop an oleogel formulation based on nyamplung seed oil as a safer and more effective alternative medicine. Apart from that, this research also aims to increase the economic value of local resources, especially for the people of Sabang City. This research used an experimental approach, involving oil extraction from nyamplung seeds, oleogel formulation, and characterization of the final product. Box-Behnken design from Response Surface Methodology was used to obtain the optimal formulation. It is expected that the research will produce an oleogel product with effective and safe anti-inflammatory activity, thereby increasing the utilization of local natural resources for the health and welfare of the people of Aceh, especially Sabang City.