Research Progress on the Mechanism of Fibrosis in Diabetic Kidney Disease and the Treatment of Traditional Chinese Medicine

肾纤维化是以肾组织损伤，炎症浸润，细胞外基质(ECM)沉积和上皮细胞间充质转化产生瘢痕为主要特点的重要病变表现。其具体的发病机制错综复杂，但糖尿病肾病(DKD)是诱发肾纤维化的主要病因之一。纤维化是所有慢性肾脏疾病(CKD)迁延变化的最终途径，现已被认为是慢性肾脏疾病进展的独立风险因子，研究肾纤维化的发病机制，对于遏制和改善各种原因导致的慢性肾脏疾病具有重大意义。本文以糖尿病肾病相关性肾纤维化分子因子机制和中医药成果展开论述，期望为临床延缓慢性糖尿病肾病纤维化进程提供一定的理论依据。Renal fibrosis is an important pathological manifestation characterized by renal tissue injury, inflammatory infiltration, extracellular matrix (ECM) deposition, and epithelial-mesenchymal transition leading to scar formation. Its specific pathogenesis is complex and intricate, but diabetic kidney disease (DKD) is one of the main causes of renal fibrosis. Fibrosis is the ultimate pathway of chronic kidney disease (CKD) progression, and is now considered an independent risk factor for the progression of chronic kidney disease. Studying the pathogenesis of renal fibrosis is of great significance for controlling and improving chronic kidney disease caused by various reasons. This article discusses the molecular mechanism of renal fibrosis associated with diabetic kidney disease and the achievements of traditional Chinese medicine, hoping to provide a certain theoretical basis for delaying the progression of chronic diabetic kidney disease fibrosis in clinical practice.