Thrombocyte profile in cordblood of newborns to diabetic and non-diabetic mothers

Background: Individuals with genetic or metabolic predisposition towards diabetes are incapable of compensating adequately for diabetogenic effect of pregnancy, causing morbidity and mortality effects in gestational diabetes. In normal pregnancy the capacity to secrete Insulin increases with gestational age and is most striking during the last trimester of pregnancy. Methods: Automated heamatology analyser ABXMICROsot was used to analyze cord blood of 40 diabetic mother born neonates and 40 non-diabetic mother born neonates, collected in EDTA tubes. Diabetic group sub-divided as D1and D2, 100-150mg/dci mother’s blood sugar level and above 150mg/dcl. Statistical treatment of Leavene’s test of equality of variances was applied to the data. Results: Significant decrease in platelet count, increase in mean platelet volume in cord blood of neonates to diabetic mothers no significant difference in platelet distribution width was noted between the two groups. Significantly higher values in D2 than D1 group. Discussion: Immunological properties are practically under the control of IL-1 & 1L-6. Interlukins-6 potentiates the action of other interleukins like IL-1 synergistically such action of interleukins convert uncommitted stem cells to committed stem cells, the immune suppressant status in diabetic mother (i.e., non-priming of neonatal IL-6 by immune suppressant diabetic mother`s IL-6 is offered as the main cause for these altered counts) by modulating neonatal IL-6 decreasing hematopoietic potential in the neonates on the other hand ECF in infants of diabetic mother is reduced leading to hemoconcentration & pictures as if increase in cell counts.