Carbamothioate-mediated Selectfluor™ oxidation for the synthesis of benzenesulfonyl fluorides in chalcone derivatives
A carbamothioate-mediated method for synthesizing benzenesulfonyl fluorides <i>via</i> Selectfluor™ oxidation is reported, enabling compatibility with α,β-unsaturated chalcone derivatives without Michael addition side reactions. This approach offers moderate yields, broad functional group tolerance, and applications in covalent drug discovery, facilitating the incorporation of sulfonyl fluoride warheads into complex electrophilic scaffolds.
Authors
- Yan Zou (ORCID: https://orcid.org/0000-0002-5266-7275)
- Zhou Ai-qing
- Xiaoyun Chai (ORCID: https://orcid.org/0000-0001-9688-9091)
- Boning Wang
- Qingjie Zhao (ORCID: https://orcid.org/0000-0002-3368-1290)
- Conghao Gai (ORCID: https://orcid.org/0000-0001-6760-5045)
- Juan Zhang (ORCID: https://orcid.org/0009-0006-1545-2677)
- Boye Jiang (ORCID: https://orcid.org/0009-0006-1864-7701)
- Qing-Guo Meng
Institutions
- Second Military Medical University (CN)
- Yantai University (CN)
Publication Details
- Journal
- RSC Advances
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5ra03427b
- Primary Topic
- Fluorine in Organic Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China