Tyrosine kinase inhibitors were well-tolerated among patients with different etiologies of advanced HCC with lower survival in non-viral patients
We studied the characteristics and survival of patients with sorafenib-treated HCC and impact of underlying etiology on outcomes. This retrospective multicenter study recruited patients with sorafenib-treated advanced HCC (12/2016 to 4/2023) till death or the study end (2/2024). Time to progression (TTP) and overall survival (OS) were recorded. We evaluated; Clinico-laboratory and imaging predictors of OS, The impact of underlying etiology on tumor variables, outcomes and tolerance for sorafenib > 6 months. This study included 706 patients. Median duration of Sorafenib therapy was 240.00 (90.00-360.00) days. Median OS was 314.00(146.00-601.00) days. Median TTP was 180.00(90.00-330.00) days. COX regression revealed that the independent factors of mortality were baseline AST, Tumor size, hepatic vein thrombosis (HVT), development of jaundice and shifting to Regorafenib. Advanced HCCs were more common on top of non-cirrhotic non-viral and HBV-related liver disease. Adverse events, TTP and tumor response didn't differ with the underlying etiology. Median OS was lower in non-viral-related HCC than HCV-related HCC (218.00 versus 326.50 days, P-value = 0.048). Patients who continued sorafenib > 6 months had lower AFP, HVT, adverse effects and better tumor response after 3 months. OS is lower in non-viral Sorafenib-treated HCC compared with viral-related HCC and Sorafenib was well-tolerated among different HCC etiologies.
Authors
- Ahmed Ramadan
- Nevien Fouad Elfouly
- Ahmed Abdelmaksoud (ORCID: https://orcid.org/0000-0002-7948-2676)
- Mohamed Bassam
- Hend Ibrahim Shousha (ORCID: https://orcid.org/0000-0002-0928-4738)
- Tamer Elbaz (ORCID: https://orcid.org/0000-0003-0816-9575)
- Eman Barakat (ORCID: https://orcid.org/0000-0002-1869-6355)
- Eman El‐Khateeb (ORCID: https://orcid.org/0000-0002-8365-6528)
- Mohamed Said (ORCID: https://orcid.org/0000-0001-6704-206X)
- Sayed Ahmed Sayed
- Asmaa A. Abdeltawab
- Hossam Dabees
- Nermeen Abdeen (ORCID: https://orcid.org/0000-0003-3272-4233)
- Safaa Ragab Askar (ORCID: https://orcid.org/0000-0002-0393-0487)
- Yasser Arafat Abdelrazek
- Ahmed Radwan (ORCID: https://orcid.org/0000-0003-0438-1384)
- Mona Shoukry Aziz
- Hossam Taha
- Hamdy Sayed (ORCID: https://orcid.org/0000-0003-2664-2282)
- Eman Rewisha
- Mostafa Elhelbawy (ORCID: https://orcid.org/0000-0002-9897-0405)
- Ashraf Omar Abdelaziz (ORCID: https://orcid.org/0000-0002-5370-5421)
- Mohamed El‐Kassas (ORCID: https://orcid.org/0000-0002-3396-6894)
- Abdulrahman A. Alrajhi (ORCID: https://orcid.org/0000-0003-0780-6093)
- Walaa mosaad Aboganob
- Anwar Nassief
- Ahmed Tawheed (ORCID: https://orcid.org/0000-0002-9382-8733)
- Mohamed Kohla (ORCID: https://orcid.org/0000-0001-9570-4796)
- Mohamed Mahmoud Nabil (ORCID: https://orcid.org/0000-0001-6002-9858)
- Ehab F. Moustafa (ORCID: https://orcid.org/0000-0001-8008-685X)
- Rania Lithy
- Aly M. Azmy
- Sayed Hassan Ahmed
- Mostafa Abd Alfattah Shamkh
- Mohamed Abdelmalek
- Dalia Ghoraba
- Raad Ahmed Hussein
- Mohamed A. Medhat
- Eman Marwan
- Allam Elsayed Allam
- Omnia A Seyam
Institutions
- Ain Shams University (EG)
- Cairo University (EG)
- Damanhour University (EG)
- Egyptian Atomic Energy Authority (EG)
- Menoufia University (EG)
- Helwan University (EG)
- Alexandria University (EG)
- Assiut University (EG)
Publication Details
- Journal
- Scientific Reports
- Published
- 2025-06-27
- DOI
- https://doi.org/10.1038/s41598-025-05828-x
- Citations
- 1
- Primary Topic
- Hepatocellular Carcinoma Treatment and Prognosis
- Type
- article
- Field-Weighted Citation Impact
- 1.32
Funders
- Cairo University