Synthesis of functionalized lactones: catalytic cross-coupling of 1,2-diols and allylic alcohols
Simple industrial feedstock chemicals such as allylic alcohols and 1,2-diols are cross-coupled to deliver δ-hydroxybutyrolactones. The reaction occurs through O-H bond activation <i>via</i> amine-amide metal-ligand cooperation involving allylic aldehydes, radical intermediates, and Ru(III) species, as established by EPR studies. This tandem process proceeds with the liberation of molecular hydrogen as the only green byproduct.
Authors
- Chidambaram Gunanathan (ORCID: https://orcid.org/0000-0002-9458-5198)
- Muniyandi Sankaralingam (ORCID: https://orcid.org/0000-0003-1128-6887)
- Raman Vijaya Sankar
- Priyanka Maharana
Institutions
- National Institute of Technology Calicut (IN)
- National Institute of Science Education and Research (IN)
- Homi Bhabha National Institute (IN)
Publication Details
- Journal
- Chemical Communications
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5cc02207j
- Primary Topic
- Asymmetric Hydrogenation and Catalysis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Science and Engineering Research Board