Research Progress of Lipid Droplets in the Regulation of Lipid Metabolism Function in the Central Nervous System

Lipid droplet is an organelle closely related to lipid metabolism, storing intracellular neutral lipids such as triglycerides (TAGs) and cholesterol esters (CEs) in the case of excess fatty acids. A growing number of studies have identified abnormal accumulation of lipid droplets in nerve cells during early development, aging, and neuropathy. In this review, from the perspective of lipid droplet, we first clarified the metabolism of lipid in the brain and the physiological function of lipid droplet in the central nervous system, then summarized the regulatory mechanism between lipid droplet and nerve cells in the central nervous system, and finally studied the relationship between abnormal lipid droplet metabolism and the occurrence of central nervous system diseases.