Pre-clinical allergenicity assessment of IgE epitope-targeted Der p 2 mutants demonstrate potential as hypoallergenic AIT candidates
Der p 2 epitope mutants display significantly reduced allergenicity. Particularly, the double 4C8 + 2F10 epitope mutant demonstrated a strong potential as a novel AIT vaccine candidate.
Authors
- Jill Glesner (ORCID: https://orcid.org/0009-0004-0258-4529)
- Glorismer Pena-Amelunxen (ORCID: https://orcid.org/0000-0002-6882-4714)
- Lorenz Aglas (ORCID: https://orcid.org/0000-0002-1236-5934)
- Martin D. Chapman (ORCID: https://orcid.org/0000-0002-0845-3632)
- Scott A. Smith (ORCID: https://orcid.org/0000-0001-5153-2726)
- Ronald van Ree (ORCID: https://orcid.org/0000-0003-0767-0894)
- M. Chruszcz (ORCID: https://orcid.org/0000-0001-7521-5485)
- Anna Pomés (ORCID: https://orcid.org/0000-0002-8729-1829)
- Serge A. Versteeg (ORCID: https://orcid.org/0000-0002-9729-3000)
- Kriti Khatri (ORCID: https://orcid.org/0000-0002-4757-2677)
- Mohadeseh Asghari
Institutions
- University of Salzburg (AT)
- Humak University of Applied Sciences (FI)
- Amsterdam University Medical Centers (NL)
- University of Virginia (US)
- Medical University of Vienna (AT)
- Michigan State University (US)
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-06-27
- DOI
- https://doi.org/10.3389/fimmu.2025.1623920
- Primary Topic
- Allergic Rhinitis and Sensitization
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Universität Salzburg
- National Institutes of Health
- National Institute of Allergy and Infectious Diseases